Guide device for cell migration and guide method for cell migration using such a device

摘要

Guide device (1) for cell migration comprising a support surface (2) provided with cells (3), and a substrate (5), said substrate (5) having a textured surface (6; 6 '; 6 " ) placed in front of the support surface (2) and placed in contact with the cells (3) placed on the support surface (2) in such a way that the cells (3) are confined between the support surface (2) and the textured surface (6; 6 '; 6 "), said textured surface (6; 6'; 6") having an anisotropic three-dimensional structure (8; 8 '; 8 ") having a repetition motif in accordance with a repetition axis (X), said repetition motif presenting a succession of adjacent guide spaces (15; 25; 35) according to the repetition axis (X), each of said guide spaces (15; 25 being adapted) ; 35) to receive at least a portion of one of the cells (3) and oriented according to an anisotropy address (A1; A2; A3a, A3b) to guide a displacement of the cells (3) in the direction of anisotropy (A1; A2; A3a, A3b).