HEPATITIS C VIRUS NS5B POLYMERASE INHIBITOR BINDING POCKET

摘要

The HCV NS5B polymerase, when complexed with certain inhibitors, adopts aconfirmation in which the finger loop region defined by amino acid residues 18to 35 is displaced to expose a binding pocket defined generally by amino acidresidues 392, 393, 395, 396, 399, 424, 425, 428, 429, 492, 493, 494, 495, 496,500 and 503. This newly exposed binding pocket defines a novel target in thesearch of further chemical entities which are capable of binding to HCV NS5Band modulating, or preferably inhibiting, the polymerase activity of HCV NS5B.