METHOD FOR MAKING HIGH PURITY CARDIOMYOCYTE PREPARATIONS SUITABLE FOR REGENERATIVE MEDICINE

摘要

This invention provides a new procedure for generating cardiomyocyte lineagecells from embryonic stem cells for use in regenerative medicine.Differentiating by way of embryoid body formation or in serum is no longerrequired. Instead, the stem cells are plated onto a solid substrate, anddifferentiated in the presence of select factors and morphogens. Afterenrichment for cells with the appropriate phenotype, the cells are allowed tocluster into cardiac bodiesTM, which are remarkably homogeneous and suitablefor the treatment of heart disease.