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TREATMENT OF PROTEIN FOLDING DISORDERS

机译:蛋白质折叠病的治疗

摘要

In certain embodiments, the invention is directed to a method for treating aprotein folding disorder such as Alzheimer's disease, dementia, Parkinson'sdisease, Huntington's disease and prion-based spongiform encephalopathy. Themethod comprises the administration to a subject of a compound of the formula(I) wherein A and B are independently a mono- or bicyclic aromatic group orheteroaromatic cyclic group. In preferred embodiments, the compounds are bis-indole compounds.
机译:在某些实施方案中,本发明涉及用于治疗糖尿病的方法。蛋白质折叠障碍,例如阿尔茨海默氏病,痴呆,帕金森氏病疾病,亨廷顿舞蹈病和以病毒为基础的海绵状脑病。的该方法包括向受试者施用下式的化合物(I)其中A和B独立地是单环或双环芳族基团或杂芳族环状基团。在优选的实施方案中,化合物是双-吲哚化合物。

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