N-ACYL DERIVATIVES OF AMINO ACIDS, A PROCESS FOR PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION AND USE THEREOF AS ANTIALLERGIC, ANTI-INFLAMMATORY AND HYPOLIPIDEMIC AGENTS

摘要

The present invention relates to N-acyl derivatives of amino acids andpharmaceuticallyacceptable salts thereof(see formula I)wherein n is 2 or 3; andR1 represents(see formula II) or (see formula III), R2=H, -CH3, -C2H5or pharmaceutically acceptable salts thereof, to novel processes for preparingthe same, touse thereof as anti-allergic, anti-anaphylactic, anti-inflammatory andhypolipidemic agents aswell as to a pharmaceutical composition comprising the indicated compounds inan efficientamount and to a method for treating allergic and inflammatory diseases andlipid metabolismdisorders: bronchial asthma, allergic rhinitis, pollinoses, seasonal and year-round rhinitis,allergic pneumonitis, atopic dermatitis, psoriasis, urticaria, allergic(including anaphylactic)reactions to insect stings and medicaments, cold allergy, allergicconjunctivitis, atherosclerosis,obesity, ischemic heart and cerebral disease, myocardial infarction andstroke.