METHODS OF ALTERING AN IMMUNE RESPONSE INDUCED BY CPG OLIGODEOXYNUCLEOTIDES

摘要

It is disclosed herein that agents that affect the activity and/or expressionof CXCLl6 can be used to alter the uptake of D-type CpG oligodeoxynucleo tides(D ODNs). Methods of inducing an immune response are disclosed that includeadministering agents that increase the activity and/or expression of CXCLl6and a D ODN. Methods of decreasing an immune response to a CpG ODN are alsodisclosed. These methods include administering an agent that decreases theactivity and/or expression of CXCLl6. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression ofCXCLl6 are provided.