METHOD FOR REDUCING AMYLOID DEPOSITION, AMYLOID NEUROTOXICITY, AND MICROGLIOSIS WITH (-)-NILVADIPINE ENANTIOMER

摘要

The present invention provides methods for reducing A.beta. deposition,A.beta. neurotoxicity and microgliosis in an animalor human afflicted with a cerebral amyloidogenic disease, such as Alzheimer'sdisease (AD), by administering therapeuticallyeffective amounts of the (R)-enantiomer of the dihydropyridine compoundnilvadipine, also known as (-)-nilvadipine, to the animalor human. Further provided are methods for reducing the risk of A.beta.deposition, A.beta. neurotoxicity and microgliosis in animals or humanssuffering from traumatic brain injury by administering (-)-nilvadipine afterthe traumatic brain injury and continuing treatmentfor a prescribed period of time thereafter.