Use Of Ventricular Enlargement Rate In Intravenous Immunoglobulin Treatment Of Alzheimer's Disease

摘要

#$%^&*AU2012227191B220141120.pdf#####Abstract The present invention relates to the use of MRI monitoring of ventricular enlargement rate as an objective measure for the purpose of assessing disease progression in patients suffering from Alzheimer's disease and the purpose of determining therapeutic effectiveness of treatment regimen for Alzheimer's patients. Methods for treating Alzheimer's Disease and monitoring therapeutic effectiveness are provided.1/19 Figure 1 Phase 2 Design: IVIG for Alzheimer's Disease Baseline Evaluation ) OMg Mg Mg Mg Placebo every 0.2g/kg 0.4g/kg 0.4g/kg/ 0.8g4kg/ v Mor~ th 3 Evalatio a. IVIg X 12 WEEKS Month 6 Evaluation Re-randomnization Mg I~g Mg Mg Mg1 Mg Mg Mg 0.2g4kg/ 0.4g/kg/ 0.4g/kgt 0.8/g 0.2g/kg/ 0.4g/kg/ 0.4g/kg/ 0.8g/kg/ 4 ve w 2 weeks 4 IVg X 12 WEEKS a. Month 12 Evaluation IVIg X 12 WEEKS Month 15 Evaluation IVg X 12 WEEKS Month 18 Evaluation 4