Once-a-week administration of 25-hydroxy vitamin D3 to sustain elevated steady-state pharmacokinetic blood concentration

摘要

#$%^&*AU2013203489B220150205.pdf#####ABSTRACT A composition for oral or parenteral administration comprising a single dose of 25-hydroxy-vitamin D3 sufficient to elevate the serum level in a human to a concentration in the range of 30 ng/ml to 200 ng/ml for at least 7 days and a pharmaceutically suitable carrier system, wherein subsequent single doses at least every 7 days are sufficient to sustain the serum level in a human to a concentration in the range of 30 ng/ml to 200 ng/ml at steady-state pharmacokinetics is disclosed. A method of elevating and sustaining the blood level concentration of 25-hydroxy-vitamin D3 in a human in need thereof comprising said orally administering or parenterally administering composition is also disclosed. The human in need thereof may be a human deficient in vitamin D having a serum level concentration of 25-hydroxy-vitamin D3 less than 30 ng/ml.WO 2010/011906 PCTIUS2009/051664 cc ng/mI CDIiD C) C) C) .-. CD CD CD c ED 00 cD CDD C) . . . . . . . oo CD 1D 00 CD 0.0.0 1/1