The present invention relates to novel chimeric oligomeric compounds having a plurality of alternating regions having either RNA like having northern or 3-endo conformational geometry (3-endo regions) or DNA like having southern or C2-endo/O4-endo conformational geometry. The oligomeric compounds of the present invention have shown reduction in mRNA levels in multiple in vitro and in vivo assay systems and are useful, for example, for investigative and therapeutic purposes.
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机译:本发明涉及新颖的嵌合寡聚化合物,其具有多个交替的区域,所述交替的区域具有RNA,例如具有北部或3末端构象几何形状的RNA(3末端区域)或DNA具有南部或C 2-末端/ O 4末端构象几何形状的DNA。本发明的寡聚化合物已在多种体外和体内测定系统中显示出mRNA水平的降低,并且可用于例如研究和治疗目的。
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