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NOVEL AVIAN CYTOKINES AND GENETIC SEQUENCES ENCODING SAME

机译:相同的新型AVIAN细胞因子和基因序列

摘要

The present invention relates generally to novel recombinant polypeptides having avian cytokine properties and to genetic sequences encoding same. More particularly, the present invention is directed to recombinant avian Type III interferon polypeptides, and genetic sequences encoding same, together with cellular expression systems and uses for same. Even more particularly, the present invention is directed to avian interferon- (IFN-) and functional derivatives, homologues and fragments thereof and to methods of use thereof. The molecules and cells of the present invention are useful in a wide range of applications including, but not limited to, providing a means for the treatment and prophylaxis of disease conditions, in particular avian disease conditions, or for use as an immune response modulator. Also provided are diagnostic means for screening for immune response and screening means for identifying modulators of IFN- protein or nucleic acid functionality.
机译:本发明总体上涉及具有禽细胞因子特性的新型重组多肽以及编码该多肽的遗传序列。更具体地,本发明涉及重组禽类III型干扰素多肽及其编码基因序列,以及细胞表达系统及其用途。甚至更特别地,本发明涉及禽干扰素(IFN-)及其功能性衍生物,同系物和片段及其使用方法。本发明的分子和细胞可用于广泛的应用中,包括但不限于提供用于治疗和预防疾病状况,特别是禽类疾病状况或用作免疫应答调节剂的手段。还提供了用于筛选免疫应答的诊断手段和用于识别IFN-蛋白或核酸功能的调节剂的筛选手段。

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