RESORCINOL N-ARYL AMIDE COMPOUNDS, FOR USE AS PYRUVATE DEHYDROGENASE KINASE INHIBITORS

摘要

A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Y is –CONR₁- or optionally substituted arylene or optionally substituted heteroarylene; R₁ is H, Cl, F, CH₃ or CF₃; 10 each R4 is independently H, CH₃ or F; R₅ is H or CH₃; and each R₂ and R₆ is independently (Alk)_n-R_n-(Alk)_n-Rn-(Alk)_n-X; The compounds of the invention are useful as resorcinol N-aryl amide (NAA) compounds, which are suitable for use as PDK inhibitors, for example for 15 inhibition of cancer cell proliferation.