METHOD FOR SYNTHESIZING Α-ARYL, HETEROARYL OR ALKENYL-Α,Α-2-FLUORO ALLYL STRUCTURE BY PALLADIUM CATALYSIS

摘要

Disclosed is a method for synthesizing a α-aryl, heteroaryl or alkenyl-α,α-2-fluoro allyl structure by palladium catalysis. Specifically, in the method of the present invention, a compound of formula A and a compound of formula B synthesize a compound of formula C under catalysis of a palladium salt and with existence of an alkali and/or ligand, and the compound definition is seen in the specification. The method has advantages such as being simple in raw material, easy to get, small in catalyst dosage, wide in substrate application range, simple and convenient in operation, and high in reaction efficiency, and the manufactured product is widely applied to aspects such as biological medicines, agricultural chemicals and material sciences.