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WATER-SOLUBLE VITAMIN E DERIVATIVE MODIFIED FAT-SOLUBLE ANTI-CANCER DRUG COMPOUND AND FORMULATION, PREPARATION METHOD AND USE THEREOF
WATER-SOLUBLE VITAMIN E DERIVATIVE MODIFIED FAT-SOLUBLE ANTI-CANCER DRUG COMPOUND AND FORMULATION, PREPARATION METHOD AND USE THEREOF
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机译:水溶性维生素E衍生化修饰的脂溶性抗癌药化合物及其制剂,制备方法和用途
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摘要
Disclosed is a trolox derivative-modified fat-soluble anti-cancer pharmaceutical compound having a structure as represented by formula I or II. An active moiety of the anti-cancer pharmaceutical compound, camptothecins or a camptothecin derivative, is covalently bonded to a lipophilic moiety, a trolox ester or a trolox amide, by a linking group to form the fat-soluble anti-cancer pharmaceutical compound. Also disclosed are a preparation, preparing method and use of the pharmaceutical compound.
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