CONDITIONALLY REPLICATING ADENOVIRUS AND USE THEREOF IN THE TREATMENT OF CANCER

摘要

The adenovirus comprises a heterologous nucleic acid sequence inserted in the 3' UTR region of adenoviral E1A gene, said sequence comprising a nucleotide sequence of formula (I), wherein: S1 to S10 represent DNA sequences, the same or different from one another, each one of these sequences having a length from 6 to 250 nucleotides and coding for an RNA sequence complementary to microRNA-148a sequence SEQ ID NO:1; (b) E1 to E9 represent DNA spacer sequences spacing sequences S1-S10, being these spacer sequences the same or different from one another and having a length from 3 to 20 nucleotides; and (c) a,b,c,d,e and f are the same or different from one another and represent an integer value that is selected from 0 and 1. The adenovirus of the invention shows selectivity against tumoral cells without raising pancreatic and hepatic toxicity S1-E1-S2-E2-S3-E3-S4-[E4-S5]a-[E5-S6]b-[E6-S7]c-[E7-S8]d-[E8-S9]e-[E9- S10]f (I)