POLYETHYLENE GLYCOL MONOMETHYL ETHER-POLYLACTIC ACID BLOCK COPOLYMER AND PREPARATION METHOD FOR SAME

摘要

Disclosed in the present invention is a polyethylene glycol monomethyl ether-polylactic acid block copolymer, said polyethylene glycol monomethyl ether-polylactic acid block copolymer being a block polymer formed from D, L-lactide and polyethylene glycol monomethyl ether ring-opening polymerisation, the mass ratio of polyethylene glycol monomethyl ether to D, L-lactide is 1:0.55-0.65 or 1:0.73-0.89 or 1:0.91-0.99. Also provided in the present invention is a preparation method for the block polymer. Using the block polymer as a carrier to prepare pharmaceutical micelles, the encapsulation efficiency of the prepared pharmaceutical micelles after reconstitution in water can reach 12 hours and over more than 90% of the time.