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METHOD FOR PREPARING DERIVATIVES OF 11-AMINOUNDECANOIC ACID AND 12-AMINODODECANOIC ACID

机译:制备11-氨基十一碳烯酸和12-氨基十二碳烯酸的衍生物的方法

摘要

The invention relates to a method for preparing a derivative of 11-aminoundecanoic acid or 12-aminododecanoic acid, or an ester of the latter, having the formula R-NH-(CH2)n-COOR', wherein n has a value of 10 or 11, R is an alkyl, fluoroalkyl, benzyl, or alkylbenzyl grouping, and R' is a hydrogen atom or an alkyl grouping. The method includes: reacting the starting compound, having the formula NH2-(CH2)n-COOR', with aldehyde, having the formula R=O, in a halogenated solvent such as to form an imine compound having formula R=N-(CH2)n-COOR'; and reducing the imine compound.
机译:本发明涉及一种制备式为R-NH-(CH 2 n的11-氨基十一烷酸或12-氨基十二烷酸的衍生物或它们的酯的方法。 -COOR',其中n为10或11,R为烷基,氟代烷基,苄基或烷基苄基,R'为氢原子或烷基。该方法包括:使具有式NH 2 -(CH 2 n -COOR'的起始化合物与醛进行反应,式R = O,在卤化溶剂中以形成具有式R = N-(CH 2 n -COOR'的亚胺化合物;并还原亚胺化合物。

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