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NON-HUMAN ANIMAL MODELS OF DEPRESSION AND METHODS OF USE THEREOF
NON-HUMAN ANIMAL MODELS OF DEPRESSION AND METHODS OF USE THEREOF
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机译:抑郁症的非人类动物模型及其使用方法
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摘要
The disclosure provides non-human optogenetic animal models of depression. Specifically, non-human animals each expresses a light- responsive opsin in a neuron of the animal are provided. The animal models are useful for identifying agents and targets of therapeutic strategies for treatment of depression. Examples of using the non-human animals expressing light-responsive opsin including Halorhodopsin family of light-responsive chloride pumps and Channelrhodopsin family of light-responsive cation channel proteins are described.
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