FUNCTIONALIZED HYDROXYAPATITE/GOLD COMPOSITES AS 'GREEN' MATERIALS WITH ANTIBACTERIAL ACTIVITY AND THE PROCESS FOR PREPARING AND USE THEREOF

摘要

New concept was developed for formation of human- and environmental- friendly material able to provide antibacterial activity. This material is composed of bioceramic (hydroxyapatite), metallic (gold) and organic part containing amino and thiol groups (amino acids) in the form of composite. Bioceramic part of this material is templating agent applied as a controller of growth and stability of metallic nanoparticles particle. These metallic nanoparticles have functionalized surface and they are centers of antibacterial activity of composites. Efficacy of antibacterial activity of these materials depends on selection of surface functionalization providing activity against both Gram-positive and Gram-negative bacteria. For developed materials this activity is much stronger compare to HAp/Ag composite which shows ability for their use as more favorable replacement of toxic silver. Materials were synthesized using sonochemical method, which has been developed as a novel, "green" approach for their formation.