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INFECTIOUS BRONCHITIS VACCINES DERIVED FROM IB QX-LIKE STRAINS

机译:IB QX样菌株衍生的感染性支气管炎疫苗

摘要

The present invention relates to infectious bronchitis (IB) viruses derived from a recently identified genotype of IB virus known as IB-QX, or from viruses that are genetically related to IB-QX, herein referred to as IB-QX-like viruses. The IB viruses of the invention may be live and attenuated or inactivated. Live, attenuated IB viruses of the invention may be produced by serial passaging of an IB-QX-like virus. The IB viruses of the invention are useful for, inter alia, vaccines against IB-QX and IB-QX-like viruses. Heretofore, known vaccine strains of IB viruses have proven insufficient to protect against infectious bronchitis caused by IB-QX and IB-QX-like viruses.
机译:本发明涉及传染性支气管炎(IB)病毒,其源自最近鉴定的IB病毒的基因型,称为IB-QX,或与IB-QX遗传相关的病毒,在本文中称为IB-QX样病毒。本发明的IB病毒可以是活的并且是减毒的或灭活的。本发明的减毒活IB病毒可以通过IB-QX样病毒的连续传代产生。本发明的IB病毒尤其可用于针对IB-QX和类似IB-QX的病毒的疫苗。迄今为止,业已证明,已知的IB病毒疫苗株不足以预防由IB-QX和类IB-QX病毒引起的传染性支气管炎。

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