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Particulate composition containing anhydrous crystalline 2-O--D-glucosyl-L-ascorbic acid, process for producing the same, and uses thereof
Particulate composition containing anhydrous crystalline 2-O--D-glucosyl-L-ascorbic acid, process for producing the same, and uses thereof
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机译:包含无水结晶2-O-D-葡糖基-L-抗坏血酸的颗粒组合物,其制备方法及其用途
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摘要
Disclosed are a particulate composition containing an anhydrous crystalline ascorbic acid 2-glucosid, a preparation method and a use thereof, wherein the particulate composition of the invention is significantly difficult to consolidate in comparison with the commonly used powder containing an anhydrous crystalline ascorbic acid 2-glucosid of quasi-drugs. Specifically, the particulate composition of the invention contains about 98.0 to about 99.9 wt% of ascorbic acid 2-glucosids based on anhydrides. The anhydrous crystalline ascorbic acid 2-glucosids contained in the composition has the crystallinity of more than 90% calculated based on the profile of X-Ray powder diffractometry or has dynamic vapor sorption of less than or equal to 0.01 wt% after free moisture in the powder is removed under the atmosphere of nitrogen and the remaining is kept for 12 hours at the temperature of 25C and relative humidity of 35 wt%. Provided is a particulate composition containing about 98.0 to about 99.9 wt% of anhydrous crystalline 2-O--D-glucosyl-L-ascorbic acid, which has dynamic vapor sorption of less than or equal to 0.01% after free moisture in the powder is removed under the atmosphere of nitrogen and the remaining is kept for 12 hours at the temperature of 25C and relative humidity of 35 wt%, contains D-glucoses and/or L-ascorbic acid, and has a reducing power of less than 1% over the composition.
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