PROCESS FOR THE PREPARATION OF (2Ｚ,5Ｚ)-5-(3-CHLORO-4-((Ｒ)-2,3-DIHYDROXYPROPOXY)BENZYLIDENE)-2-(PROPYLIMINO)-3-(Ｏ-TOLYL)THIAZOLIDIN-4-ONE AND INTERMEDIATE USED IN SAID PROCESS

摘要

The present invention relates to (2Z, 5Z) -5- (3-chloro-4 - ((R) -2,3- dihydroxypropoxy) benzylidene) -2- Tolyl) thiazolidin-4-one and the novel intermediate (R) -3-chloro-4- (2,3-dihydroxypropoxy) -benzaldehyde used in the process. (2Z, 5Z) -5- (3-chloro-4 - ((R) -2,3-dihydroxypropoxy) benzylidene) -2- (propylimino) -3- Jolidin-4-one is described in WO 2005/054215 as acting as an immunosuppressant. The present invention also relates to a novel process for the preparation of (R) -3-chloro-4- (2,3-dihydroxypropoxy) -benzaldehyde.