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Marker composition comprising S1P protein for prediction of risk in osteoporotic fracture and osteoporosis
Marker composition comprising S1P protein for prediction of risk in osteoporotic fracture and osteoporosis
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机译:包含S1P蛋白的标志物组合物,用于预测骨质疏松性骨折和骨质疏松的风险
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摘要
Disclosed herein is a marker composition that includes sphingosine 1-phosphate (S1P) lipid and that may be used to predict the risk of fracture or osteoporosis; a kit that includes an antibody that specifically binds to the S1P lipid and that can be used to predict the risk of fracture or osteoporosis; and a method that can be used to obtain information that allows prediction of the risk of fracture or osteoporosis and includes measurements of S1P lipid concentrations by measuring the binding of a S1P-specific antibody to SIP lipid. The S1P lipid disclosed herein is highly expressed in individuals with fracture, regardless of their bone mineral density. Accordingly, it may be useful as a biomarker of the risk of fracture or osteoporosis.
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