Trans-splicing enzymatic nucleic acid molecule specific to splicing variant of AIMP2 gene, and pharmaceutical composition for treating lung cancer and composition for diagnosing lung cancer using the same

摘要

The present invention is to target the trans-splicing variants of genes AIMP2 specifically relates to nucleic acid molecules, and pharmaceutical compositions and diagnostic composition for lung cancer therapy using the same having a splicing activity. Trans encoded by the vectors of the invention-splicing ribozyme to specifically suppressed and at the same time specific lung tissue expressing AIMP2-DX2 expressed a therapeutic gene, such as a suicide gene to AIMP2-DX2 specific and It may indicate an effective anti-cancer effect. Therefore, using the vector of the invention can be used in cancer gene therapy. In addition, by expressing a reporter gene specifically to cancer tissue expressing AIMP2 DX2-red, can be used as in vivo diagnostic and imaging reagents capable of diagnosing lung cancer progression. ;