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Antibody specifically binding to L1CAM in humans and mice, and use thereof
Antibody specifically binding to L1CAM in humans and mice, and use thereof
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机译:与人和小鼠中的L1CAM特异性结合的抗体及其用途
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摘要
The present invention relates to a novel antibody specifically binding to human and mouse L1CAM, and more particularly, to an antibody binding to both human and mouse L1CAM with high affinity, which is prepared by modifying a sequence of an L1 cell adhesion molecule (L1CAM)-specific antibody comprising a heavy-chain variable region of SEQ ID NO. 1 and a light-chain variable region of SEQ ID NO. 5, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide, a transformant introduced with the vector, a pharmaceutical composition for preventing or treating cancer comprising the antibody, a method for treating cancer using the antibody, a composition for diagnosing cancer comprising the antibody, a kit for diagnosing cancer comprising the composition, a method for providing information for cancer diagnosis using the antibody, and an antibody-drug conjugate prepared by conjugating a drug to the antibody.
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机译:本发明涉及特异性结合人和小鼠L1CAM的新型抗体,更具体地,涉及通过修饰L1细胞粘附分子(L1CAM)的序列制备的以高亲和力结合人和小鼠L1CAM的抗体。特异性抗体,其包含SEQ ID NO.1的重链可变区。 1和SEQ ID NO.1的轻链可变区。参照图5,编码抗体的多核苷酸,包含该多核苷酸的表达载体,随该载体引入的转化体,用于预防或治疗该癌症的药物组合物,使用该抗体治疗癌症的方法,包括该抗体的诊断癌症的组合物。抗体,用于诊断癌症的试剂盒,包括该组合物,提供使用该抗体进行癌症诊断的信息的方法以及通过将药物与抗体缀合而制备的抗体-药物缀合物。
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