首页> 外国专利> A NOVEL WORM-LIKE MICELLES TARGETING TUMORS BASED ON THE EXTRACELLULAR PH AND PREPARING METHOD THEREOF

A NOVEL WORM-LIKE MICELLES TARGETING TUMORS BASED ON THE EXTRACELLULAR PH AND PREPARING METHOD THEREOF

机译:基于细胞外PH的新型蠕虫状胶质瘤定位方法及其制备方法

摘要

The present invention relates to an extracellular pH sensitive worm-shaped micelle for a cancer cell, and to a preparing method thereof. A pH sensitive worm-shaped drug carrier according to the present invention has an effect of being used as a medical drug carrier by increasing treatment effect by effectively discharging a drug sealed inside by collapse of the structure caused by ionization of 3-diethylaminopropyl (DEAP) which is a pH sensitive material in a weak acid environment of a tumor cell. And the pH sensitive worm-shaped drug carrier has an effect of being used as a composition for photodynamic diagnosis or treatment of cancer by sealing chlorin e6 (Ce6) which is photosensitive material inside.
机译:本发明涉及用于癌细胞的细胞外pH敏感的蠕虫状胶束及其制备方法。根据本发明的pH敏感的蠕虫形药物载体具有通过有效释放因3-二乙氨基丙基(DEAP)的电离引起的结构崩溃而密封在内部的药物而提高治疗效果的用作药物载体的作用。在肿瘤细胞的弱酸环境中是一种pH敏感材料。 pH敏感的蠕虫状药物载体通过将作为光敏材料的二氢卟酚e6(Ce6)封入内部,具有用作光动力诊断或治疗癌症的组合物的作用。

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