Synthetic peptides FOR monospecific antibody against isoform 2 eukaryotic translation elongation factor 1A

摘要

1. A peptide derivative, to generate specific antibodies in the body interacting with 2 isoform translation elongation factor 1A humans and other mammals (assuming identity of amino acid sequences of these proteins), but do not interact with one isoform translation elongation factor 1A, of general formula IX-KSDPPQEAAQFTS -NH-CH (CHCHCOOH) -COY (X-lysyl-seryl-glutamyl-prolyl-prolyl-glutaminyl-glutamyl-alanyl-alanyl-glutaminyl-phenylalanyl-seryl-threonyl-glutamate or -glutamatamid) (I), or a pharmaceutically acceptable salt thereof, or a salt thereof vat where X - acetyl group or a hydrogen atom, Y-NH- or OH-group, and the remainder of the peptide derivative is a fragment of the amino acid sequence 2 isoform of human translation elongation factor 1A, comprising amino acid residues 330 № № 343.2. Method production in an animal monospecific antibodies reactive with isoform 2 translation elongation factor 1A humans and other mammals (assuming identity of amino acid sequences of these proteins), but not interacting with the isoform 1 of this factor, comprising administering to the animal an effective dose of conjugate peptide derivative of claim. 1 with a carrier protein in a composition with a publicly known adyuvantami.3. Use of the peptide derivative of claim 1 for affinity purification of monospecific antibodies reactive with 2 isoform translation elongation factor 1A humans and mammals, but not interacting with the isoform 1 of faktora.4. A method for determining isoform 2 translation elongation factors 1A humans and other mammals (provided that they frag