NEW COMPOUNDS INFLUENCING FOOD BEHAVIOR

摘要

1. The PYY analogue containing the amino acid sequence expressed by the formula (I) Xaa-Ile-His-Pro-His-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Xaa-His- Tyr-Xaa-Xaa-Xaa-Leu-Xaa-His-Tyr-Leu-Asn-Xaa-Val-Thr-Arg-Gln-Arg-Tyr-NH [SEQ ID NO: 1] (I) in which Xaa is selected from the group consisting of Pro and Gly; Haav selected from the group consisting of Leu, Ile and Lys; Xaa selected from the group consisting of Tug and Phe; Haav selected from the group consisting of Ile, Leu, Ala and Val; Haav selected from the group consisting of Ala, Leu, Gly, Val and Ser; Xaa selected from the group consisting of Arg and His; and Haa is selected from the group consisting of Leu and His; or a compound representing a variant thereof and / or a derivative thereof; or a salt thereof, including a salt of the indicated variant and / or derivative, wherein the variant is an amino acid sequence in which there are up to two amino acids, except for Haa, Haa, Haa, Haa, Haa, Haai Haa, replaced by another amino acid. 2. An analog of PYY according to claim 1, which is not an option. 3. The PYY analogue of claim 1, wherein Haaprepresent Pro [SEQ ID NO: 18]. 4. The PYY analogue of claim 3, wherein Haap is Leu [SEQ ID NO: 21] .5. The PYY analogue of claim 4, wherein Ha is Pro; Haap is Leu; Haap is Tug; Haap is Ile or Leu; Haap is Ala; Haav is selected from the group consisting of Arg or His; and Haav is selected from the group consisting of Leu and His [SEQ ID NO: 47] .6. The PYY analogue of claim 5, wherein Haaprepresents Arg [SEQ ID NO: 28]. 7. The PYY analogue according to claim 6, wherein Haap is Ile [SEQ ID NO: 26] .8. The PYY analogue of claim 6, wherein Haaprepresents Leu [SEQ ID NO: 25] .9. The PYY analogue of claim 7, wherein Haap is Leu [SEQ ID NO: 31] .10. The PYY analogue according to claim 1, which is a derivative modified by one or more processes selected from amidation, glycosylation, carbamylation,