SYNTHESIS OF THE NEW FUCOSE- COMPRISING OF THE DERIVED HYDROCARBONS

摘要

1. A process for preparing a compound of formula 1 or a salt thereof ,, wherein A is a carbohydrate linker which represents laktozilny residue or consisting of laktozilnogo residue and at least one monosaccharide unit selected from the group consisting of glucose, galactose, N -atsetilglyukozamina, fucose and N-acetylneuraminic acid; and wherein R is one of the following anomeric protecting groups: a) -OR, wherein R is a protecting group removable by catalytic hydrogenolysis, b) -SR, where R is optionally substituted alkyl, optionally substituted aryl or optionally substituted benzyl, c) -NH-C (R '') = C (R '), wherein each R' independently represents an electron withdrawing from the following groups: -CN, -COOH, -COO-alkyl, -CO-alkyl, -CONH, - CONH-alkyl or -CON (alkyl), or wherein two R'-groups are joined together and form a -CO- (CH) -CO- and thus form together with the carbon atom to which they are attached, a 5-7 membered cycloalkane-1,3-dione, wherein any of the methylene groups is optionally substituted with 1 or 2 alkyl groups and R '' represents H or alkyl, wherein fucosyl donor is of formula 2 wherein X is selected from the group consisting of: guanozindifosfatilnogo residue, a lactose residue, azide, fluoride, optionally substituted phenoxy, optionally substituted pyridinyloxy, optionally substituted 3-oxo-furaniloksi formula A optionally substituted 1,3,5 -triaziniloksi The formulas are, 4-metilumbelliferiloksi group of formula a group of formula C and D, where independently represents H or alkyl, or two adjacent groups R a group = C (R), wherein the pre independently