Adenogennogo method of treating locally advanced cancer of the rectum nizhneampulyarnogo comprising 5-fluorouracil chemotherapy, drug therapy, gamma-dynamic therapy scheme dose fractionation, wherein the 5-fluorouracil is administered at adrectal tissue adjacent to the tumor in the volume 5-15 mL for 5-15 minutes before the session before the first irradiation by three major fractions, and as the drug therapy is carried infusional MabThera at a dose of 50-70 mg / MZA 50-60 minutes prior to radiotherapy in 1, 7 and 14 days of treatment, When this 1 to 12 days from start of treatment radiation therapy on the tumor and metastasis to regional zones 2-4 fields in the dynamic fractionation mode ROD = 3.6 Gy and more №3 with ROD = 2.2-2.4 Gy №9 to SOD = 32,4-34,8 gr.
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