METHOD OF OBTAINING SUBSTITUTED THOSE IT AND QUINOLINE FROM ANILINE, 1, 3 - DIOLS AND CCL4 UNDER THE INFLUENCE OF catalysts iron-containing

摘要

A method for preparation of substituted quinolines of formula, by reacting anilines with 1,3-diols by the action of catalysts, characterized in that the substituted anilines of formula XCHNH, wherein X - as defined above, is reacted with a 1,3-diol (1,3-propanediol or 1, 3-butanediol) and CClv presence of a catalyst selected from a number of FeCl · 6HO, FeCl, FeCl · 4HO, Fe (CH), Fe (acac), Fe (OAc) and Fe (CO) at a molar ratio [catalyst]: [aniline ]: [CCl]: [the diol] = 1: 100: 200: 400, at 150 ° C for 8 hours, the resulting reaction mixture is neutralized, the organic layer was extracted with CHCl, filtered and evaporated races voritel.