METHOD FOR DELIVERY OF MEDICINES FOR PTH, PTH-P AND RELATED PEPTIDES

摘要

1. An array of microprotrusions suitable for transdermal drug delivery, wherein said array of microprotrusions contains a substrate material with a plurality of attached microprotrusions, wherein at least one of said microprotrusions has a coating of a dosage form containing [Glu, Leu, Aib, Lys] hPTHrP (1-34) NH.2. The microprotrusion array according to claim 1, wherein said microprotrusion contains a polycarbonate polymer. 3. An array of microprotrusion according to claim 1, wherein said microprotrusion contains a liquid crystal polymer. The microprotrusion array according to claim 1, wherein said microprotrusion has a base with a width greater than twice the width at the apex. 5. The microprotrusion array according to claim 1, wherein said microprotrusion has a base with a width greater than four times the width at the apex. The microprotrusion array according to claim 1, wherein said microprotrusion has a base with a width greater than six times the width at the apex. 7. The microprotrusion array of claim 1, wherein said microprotrusion are microneedles. An array of microprotrusions according to claim 1, wherein said microprotrusion have a pyramidal shape. The microprotrusion array according to claim 1, wherein said microprotrusion have a rectangular base and a rectangular vertex. 10. The microprotrusion array according to claim 1, wherein said microprotrusion has a square base and a square top. The microprotrusion array according to claim 1, wherein said microprotrusion has an elastic modulus in bending from about 8000 MPa to about 12000 MPa (ISO 178) .12. The microprotrusion array of claim 1, wherein said microprotrusion has a flexural modulus of from about 9000 MPa to about 10,000 MPa (ISO 178) .13. The microprotrusion array according to claim 1, wherein said microprotrusion have an elastic modulus