RECOMBINANT PSEUDO-ADENOVIRUS PARTICLE, WHICH PRODUCES MODIFIED NANO-ANTIBODIES, WHICH LEARN THE MYCOPLASMA Of M.hominis, PHARMACEUTICAL COMPOSITION HUMS TO ITS BASIS AND METHOD OF ITS USE FOR THE THERAPY OF MYCOPLASMOSES

摘要

1. Recombinant psevdoadenovirusnaya particle on the basis of human adenovirus serotype 5 genome, containing an expression cassette with the modified chimeric gene insert nanoantibody binding to mycoplasma M.hominis, the nucleotide sequence of which is pre-modified by attaching an effector Fc-fragment of immunoglobulin G.2. Recombinant particles according to claim psevdoadenovirusnaya. 1, characterized in that the pre-modified nanoantibody gene sequence is the nucleotide sequence of SEQ ID 1.3. Recombinant psevdoadenovirusnaya particle according to claim. 1, characterized in that it activates the complement system mlekopitayuschih.4 immune system. A pharmaceutical composition comprising recombinant particles according to claim psevdoadenovirusnye. 1 and a pharmaceutically acceptable carrier, wherein upon administration to a mammal it activates the complement system and suppresses mycoplasma M.hominis.5. Method mycoplasma therapy M.hominis, by administering to a mammal in need thereof a therapeutically effective amount of a pharmaceutical according to claim. 4.6 composition. The method of claim. 5, characterized in that the pharmaceutical composition is administered by intravenous injection.