COMBINATION OF FIXED DOSES OF BIMATOPROST AND BRIMONIDINE

摘要

1. A local composition for ophthalmic use for use to lower intraocular pressure in a patient, containing about 0.01% w / w. bimatoprost and about 0.1% wt./weight. brimonidine. 2. The local composition according to claim 1, characterized in that bimtoprost is in a concentration of 0.01% wt./weight., And brimonidine is brimonidine tartrate and is in an amount of 0.1% wt./weight. in aqueous carrier. 3. The local composition of claim 2, further comprising a solubilizer selected from the group consisting of Na-CMC and Soluplus®. 4. The local composition of claim 2, further comprising buffering agents selected from the group consisting of dibasic sodium phosphate heptahydrate, citric acid monohydrate, sodium borate decahydrate, sodium hydroxide, and hydrochloric acid. The local composition of claim 2, further comprising tonicity control agents, wherein said tonicity control agents are selected from the group consisting of NaCl and glycerol. The local composition of claim 2, further comprising preservatives, wherein said preservatives are selected from the group consisting of benzalkonium chloride and purite. The local composition according to claim 2, characterized in that said composition is a solution, and it is administered at least once a day. The local composition according to claim 2, characterized in that the composition is administered twice a day. The local composition according to claim 2, characterized in that said composition is suitable for the treatment of glaucoma, wherein said glaucoma is selected from the group consisting of open-angle glaucoma, angle-closure glaucoma, narrow-angle glaucoma, normotensive glaucoma, and con