SPECIFIC IN RESPECT TO AMYLOID BETA (A BETA) 1-42 MONOCLONAL ANTIBODIES WITH THERAPEUTIC PROPERTIES

摘要

1. An antibody or active fragment thereof that binds to an Aβ peptide, wherein said antibody contains all six complementarity determining regions (CDRs) of a monoclonal antibody obtained from FP 12H3-C2 hybridoma cell line, deposited on December 01, 2005 as DSM ACC2750.2 . The antibody or its active fragment, where the specified antibody, or its active fragment, contains the variable region of the light chain (LCVR) with the sequence SEQ ID NO: 7 and / or the variable region of the heavy chain (HCVR) with the sequence SEQ ID NO: 8.3. An antibody according to claim 1 or 2, which is a monoclonal antibody. An antibody or active fragment thereof according to claim 1 or 2, wherein the antibody recognizes and binds to at least two individual binding sites on a β-amyloid protein, where at least two individual binding sites contain at least one amino acid residue and at least two sequentially located amino acid residues, respectively, which are mainly involved in the binding of the antibody, where at least one residue forming the first individual binding site is a Leu, and at least m The two consecutive amino acid residues forming the second individual binding site are -Phe-Phe-, located in the following crustal sequence: -Xaa-Haa-Haa-Leu-Haa-Phe-Phe-Xaa-Haa-Haa, where Xaa denotes an amino acid residue selected from the group consisting of His, Asn, Gln, Lys, and Arg; Haa is an amino acid residue selected from the group consisting of Asn and Gln; Haa is an amino acid residue selected from the group consisting of Lys, His, Asn, Gln, and Arg; Haa denotes the amino acid residue