TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS FOR USING THEM FOR PSMA INHIBITION

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to new radiopharmaceutical compounds of structural formula ; . ;In formula I, R means H or a (C₁-C₈)alkyl group; W means a bond, -CH(NH₂)-, -C(O)-NH-CH(COOH)-, -O-(CH₂)_n-O-(CH₂)_n- or -(CH₂)_nO(CH₂)_nO(CH₂)_n; Z means -NHC(O)-, -NH-C(O)-CH(NH₂)- or -C(O)-NH-CH(COOH)-; e is an integer from 1 to 4; f is an integer from 0 to 10; g is an integer from 0 to 10; n is an integer from 0 to 2; the radical NR^aR^b values are presented in the patent claim.;EFFECT: invention refers to the radionuclide complex containing a radioactive metal and the above compounds, to a pharmaceutical compound for visualising and to a method for visualising any patient's region, e.g. a tissue specified in the spleen tissue, kidney tissue or PSMA-expressing tumour tissue.;21 cl, 6 dwg, 1 tbl, 18 ex