METHOD FOR MAKING AND PRESCRIBING SPHAELACTONE DERIVATE AND ITS COMPOSITES

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to micheliolide derivatives of formula , a based pharmaceutical composition and using them for treating cancer. In formula (I) R₁ represents H, -C(O)R₄, wherein R₄ represents C_1-8alkyl; R₂=R₃ represents a double bond, or R₃ represents H, and R₂ represents substituted alkyl having from 1 to 8 carbon atoms, wherein a substitute represents -NR₇R₈; or its pharmaceutically acceptable salts; and wherein R₇ and R₈ can be identical or different, and represent C_1-8alkyl; X represents oxygen; Y represents a single bond.;EFFECT: preparing the pharmaceutical composition for treating cancer.;6 cl, 1 tbl, 8 ex