COMPOSITIONS OF ORALLY DISPERSIBLE TABLETS CONTAINING COMBINATIONS OF HIGH- AND LOW-DOSE THERAPEUTIC AGENTS

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: present invention aims at pharmaceutical compositions containing a number of microparticles with taste masking, containing high-/low-dose therapeutic agents, at dosage forms containing the above pharmaceutical compositions (such as orally dispersible tablets), and at methods for producing these pharmaceutical compositions and dosage forms.;EFFECT: dosage forms containing the pharmaceutical compositions according to the invention represent the improved homogenous mixtures of the high-dose and low-dose therapeutic agents, which enable controlling the release rate of the therapeutic agent from particles by various ways, as well as flexible correction of dosages when administering the combinations of the therapeutic agents, eg in pain management.;31 cl, 4 dwg, 12 tbl, 8 ex