METHOD OF OBTAINING SUBSTANCE BASED ON OXIDATED DEXTRAN AND ISONICOTINIC ACID HYDRAZIDE

摘要

FIELD: chemistry.SUBSTANCE: invention represents method of obtaining substations based on oxidated dextran and isonicotinic acid hydrazide, which includes obtaining dextran water solution, dextran oxidation with potassium permanganate in acidic medium at heating, removal of admixtures from solution by filtration, purification of oxidated dextran water solution from manganese ions by passing at rate 100-600 ml/min through cation exchange resin, represented by cationite based on styrene copolymer with static volume capacity 1.9 g-eq/cm, addition of powder of isonicotinic acid hydrazide and distilled water or water solution of isonicotinic acid hydrazide.EFFECT: simplification of process of obtaining substance based on oxidated dextran and isonicotinic acid hydrazide for pharmaceutical application due to creation of conditions for minimisation of stages and used reagents with elimination of application of dangerous reagents and simultaneous obtaining target product, free of manganese ions.2 ex