METHOD FOR DETERMINING HIGH THROMBOGENIC RISK IN PREGNANCY FOR HEPARIN PREVENTION

摘要

FIELD: medicine.SUBSTANCE: method involves measuring a peak thrombin concentration (PTC) and an endogenous thrombin potential (ETP) in thrombin generation test; if PTC is more than 367.91 nmol/l in 6-8 weeks pregnant females; 444.84 nmol/l in 12-13 weeks pregnant females; 479.74 nmol/l in 22-24 weeks pregnant females and 488.06 nmol/l in 34-36 weeks pregnant females, and/or ETP is more than 2164.53 nmol/min in 6-8 weeks pregnant females; 2444.15 nmol/min in 12-13 weeks pregnant females; 3072.34 nmol/min in 22-24 weeks pregnant females and 2849.63 nmol/min in 34-36 weeks pregnant females, the above females are stated to have a high thrombogenic risk and need heparin prevention. The presented method is easy to implement and high-informative.EFFECT: invention can be used for determining a high thrombogenic risk in the pregnant females in need of heparin prevention, for reducing a rate of venous thromboembolic complications and improving the clinical outcomes of pregnancies.1 ex, 2 dwg