System and method for the integrated and predicative analysis of molecular, image and clinical data for the patient-specific management of diseases

摘要

A system that operates in a plurality of modes to provide integrated analysis of molecular data, image data, and clinical data associated with a patient includes a multi-scale model, a molecular model, and a linking component. The multi-scale model is configured to generate one or more estimated multi-scale parameters based on the clinical data and the image data when the system is operating in a first mode and to generate a model of organ functionality based on one or more derived multi-scale parameters when the system works in a second mode. The molecular model is designed to generate one or more first molecular results based on a molecular network analysis of the molecular data, the molecular model being constrained by the estimated parameters when the system is operating in the first mode. The linking component, operably coupled to the multiscale model and the molecular model, is designed to transfer the estimated multiscale parameters from the multiscale model to the molecular model when the system is operating in the first mode, and using a machine learning process to derive the derived multiscale parameters based on the molecular Generate results when the system is operating in the second mode.