STIMULATION REAGENT, SKIN SUBSTITUT, EXPLANT CUTANE AND METHOD FOR REPRODUCING THE PHYSIOPATHOLOGY OF ATOPIC DERMATITIS

摘要

The present invention relates to a pro-inflammatory stimulation reagent containing: a. Between 10 and 500 ng / mL interleukin IL-1β, and b. Between 3 and 20 μg / mL of a TLR-2 receptor ligand, and / or c. Between 3 and 20 μg / mL of a ligand of the TLR-3 receptor, as well as its use to reproduce in vitro the pathophysiology of atopic dermatitis and / or alter the barrier function in a skin substitute or in a skin explant.