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IG-P CONSENSUS GENE VACCINATION PROTECTS FROM ANTIBODY-DEPENDENT IMMUNE PATHOLOGY IN AUTOIMMUNE DISEASE
IG-P CONSENSUS GENE VACCINATION PROTECTS FROM ANTIBODY-DEPENDENT IMMUNE PATHOLOGY IN AUTOIMMUNE DISEASE
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机译:自身免疫性疾病相关抗体的IG-P共识基因疫苗保护。
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摘要
The disclosure provides methods and compositions useful for treating autoimmune diseases and disorders. For example, the disclosure demonstrates that hypergammaglobulinemia and subsequent accelerated kidney disease can be suppressed by Ig minigene-induced CD8+ T cells that make CD4+ T cells hyporesponsive to antigenic stimulation, thus causing inhibition of renal disease and subsequent increased survival.
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