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PREPARATION METHOD OF FLUMAZENIL LABELED WITH FLUORINE-18 USING DIARYL IODONIUM SALT PRECURSOR
PREPARATION METHOD OF FLUMAZENIL LABELED WITH FLUORINE-18 USING DIARYL IODONIUM SALT PRECURSOR
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机译:二碘碘鎓盐前体法制备含氟18的氟氮腈的方法
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摘要
Disclosed is the synthesis of [ 18 F]flumazenil that is useful in imaging epileptic lesions by PET (positron emission tomography). A method for preparing [ 18 F]flumazenil by reacting a diaryliodonium salt precursor with the positron-emitting radionuclide fluorine-18. [ 18 F]flumazenil can be prepared from the diaryliodonium salt precursor in the presence of kryptofix 2.2.2. /potassium carbonate(K 2.2.2. /K 2 CO 3 ) and TEMPO in dimethylformamide (DMF) at a high yield.
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机译:公开了[18 F]氟马西尼的合成,其可用于通过PET(正电子发射断层摄影)对癫痫病灶成像。一种通过使二芳基碘鎓盐前体与发射正电子的放射性核素氟18反应制备[18 F]氟马西尼的方法。 [18 F]氟马西尼可以在存在kryptofix 2.2.2的情况下由二芳基碘鎓盐前体制备。碳酸钾(K 2.2.2。/ K 2 CO 3)和TEMPO在二甲基甲酰胺(DMF)中的产率很高。
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