8-AZA-3,7-DIDEAZAADENINE NUCLEOSIDE DERIVATIVES, 8-AZA-3,7-DIDEAZAADENINE NUCLEOTIDE DERIVATIVES AND POLYNUCLEOTIDE DERIVATIVES AS WELL AS PROBES

摘要

PROBLEM TO BE SOLVED: To provide a fluorescent nucleoside excellent in base discrimination ability, the fluorescent nucleoside being able to change a fluorescent emission wavelength depending on a difference in a surrounding polar environment without destabilizing a DNA double helix structure even when introducing into DNA, and to provide a probe using it.SOLUTION: Disclosed are a compound represented by formula (I) and a polynucleotide derivative containing the compound. [Ris an H or OH; X is a single bond, carbon double bond (-C=C-), or carbon triple bond (-C≡C-); and Ris 2-3 condensation 6 membered-rings.]SELECTED DRAWING: Figure 1