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USAGE OF RECOMBINANT LISTERIA STRAINS IN MANUFACTURING MEDICAL DRUG FOR DELAYING ONSET OF BRAIN TUMOR OR MAMMARY GLAND TUMOR
USAGE OF RECOMBINANT LISTERIA STRAINS IN MANUFACTURING MEDICAL DRUG FOR DELAYING ONSET OF BRAIN TUMOR OR MAMMARY GLAND TUMOR
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机译:重组李斯特菌菌株在制造医用药物中延缓脑肿瘤或乳腺肿瘤发作的用途
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PROBLEM TO BE SOLVED: To provide a composition and a method for treating an Her2/neu antigen-expressing tumor, vaccinating against the tumor, and inducing immune response to dominant epitope of the antigen and several sub-dominant epitopes.SOLUTION: An immunogenic composition containing fusion polypeptide contains an Her2/neu chimeric antigen in which the fusion polypeptide is fused into further polypeptide, and administration of the fusion protein to a subject having the Her2/neu expressing tumor prevents escape mutation in the tumor.SELECTED DRAWING: Figure 3
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