Biocatalytic synthesis of optically pure (R) and (S) 3-methyl-1,2,3,4-tetrahydroquinoline and antithrombotic (21R)-and (21S) -argatroban Its use as a chiral synthon for preparation

摘要

The present invention relates to biocatalytic synthesis of enantiomerically pure (3R) and (3S) -methyl-1,2,3,4-tetrahydroquinoline. Said enantiomerically pure compounds are useful as chiral synthons in organic synthesis, in particular for the preparation of diastereomerically pure (21R) and (21S) -argatroban and analogues thereof. Also disclosed are new compounds for use as intermediates in the methods of the invention.