Modified BET protein inhibitory dihydroquinoxalinones and dihydropyridopyrazinones

摘要

The present invention relates to BET protein inhibitory activity of general formula (I), wherein A, X, R1, R2, R3, R4, R5, R6 and n are each as defined in the specification, In particular, BRD4 inhibitory dihydroquinoxalinones and dihydropyridopyrazinones, intermediates for the preparation of the compounds of the invention, pharmaceutical compositions comprising the compounds of the invention, and cases of hyperproliferative disorders, in particular neoplastic disorders Related to its preventive and therapeutic use in cases. The invention further relates to the use of BET protein inhibitors in viral infections, neurodegenerative disorders, inflammatory diseases, atheropathic disorders and male fertility control. [Chemical 1]