NOVEL FORMULATION OF CILOSTAZOL, QUINOLINONE DERIVATIVE USED FOR ALLEVIATING SYMPTOM OF INTERMITTENT CLAUDICATION IN PATIENTS WITH PERIPHERAL VASCULAR DISEASE

摘要

PROBLEM TO BE SOLVED: To provide extended-release forms of cilostazol pharmaceutical compositions.SOLUTION: A pharmaceutical composition is in solid form containing particulate cilostazol or a salt thereof, a cellulose, a diluent, and a lubricant. The pharmaceutical composition features an in vivo plasma profile for cilostazol of C/C0.25. Also disclosed is a method of preparing the pharmaceutical composition.SELECTED DRAWING: Figure 5