Avoiding the risk of narcolepsy in influenza vaccines

摘要

The present invention provides influenza vaccines and methods that improve in relation to the safety of influenza vaccines, and more particularly to the risk of causing narcolepsy in adjuvanted vaccines. In one aspect, an influenza vaccine composition comprising influenza virus A nucleoprotein is provided, wherein the fragment of the nucleoprotein equivalent to amino acids 106-126 of SEQ ID NO: 2 is a peptide having the amino acid sequence shown in SEQ ID NO: 1 With a lower affinity, the vaccine composition binds to an MHC class II receptor comprising HLA DQB1 * 0602, but if the total influenza A nucleoprotein in the composition comprises the amino acid sequence shown in SEQ ID NO: 12, It is not based on the NYMC X-181 strain derived from the A / California / 7/2009 (H1N1) strain.